Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.42 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2176120 | 0.87 | HDAC1 (0.44) | — | |
| SCHEMBL1223765 | 0.85 | HSD11B1 (0.56) | HSD11B1HSD11B2 | |
| SCHEMBL3709779 | 0.84 | OPRD1 (0.39) | HSD11B1HSD11B2MEN1MAPTKMT2A | |
| SCHEMBL12408216 | 0.78 | KDM1A (0.37) | MEN1MAPTKMT2ANPSR1 | |
| SCHEMBL2175333 | 0.78 | HSD11B1 (0.44) | HSD11B1HSD11B2 | |
| SCHEMBL1223056 | 0.72 | HSD11B1 (0.56) | HSD11B1HSD11B2SIGMAR1 | |
| SCHEMBL2802804 | 0.70 | HRH3 (0.55) | HRH3TDP1ALDH1A1NPY5ROPRM1 | |
| SCHEMBL1223122 | 0.70 | HSD11B1 (0.53) | HSD11B1HSD11B2HRH3MEN1KMT2A | |
| SCHEMBL1222605 | 0.69 | HSD11B1 (0.80) | HSD11B1HSD11B2 | |
| SCHEMBL1223443 | 0.69 | HSD11B1 (0.59) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2207549-A1 | MODULATORS OF MUSCARINIC RECEPTORS | Vertex Pharmceuticals Incorporated (US) | 2010-07-21 | — | — | EP | disclosed |
| WO-2009045519-A1 | MODULATORS OF MUSCARINIC RECEPTORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-04-09 | — | — | WO | disclosed |