Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | NPY4R | P50391 | 4/20 | 0.34 |
| ▸ | NPY1R | P25929 | 3/20 | 0.34 |
| ▸ | NPY2R | P49146 | 2/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL7576309 | 0.96 | REN (0.38) | CTSCANPEPRNPEPDNPEPREN | |
| Arginine SCHEMBL3656565 | 0.94 | CTSC (0.41) | CTSCANPEPRNPEPDNPEPREN | |
| Arginine SCHEMBL8619483 | 0.92 | KDM1A (0.37) | GHSRKDM1A | |
| Arginine SCHEMBL8614042 | 0.92 | KDM1A (0.37) | GHSRKDM1A | |
| Arginine SCHEMBL3251258 | 0.92 | KDM1A (0.36) | ANPEPRNPEPDNPEPRENNPY4R | |
| Arginine SCHEMBL9702449 | 0.91 | KEAP1 (0.37) | CTSCRENMAPK8MAPK9MAPK10 | |
| Arginine SCHEMBL515138 | 0.91 | CTSC (0.43) | CTSCANPEPRNPEPDNPEPALPI | |
| Arginine SCHEMBL285989 | 0.91 | CTSC (0.43) | CTSCANPEPRNPEPDNPEPALPI | |
| Arginine SCHEMBL29129604 | 0.91 | CTSC (0.43) | CTSCANPEPRNPEPDNPEPALPI | |
| Arginine SCHEMBL29206209 | 0.91 | PRCP (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0079934-A4 | ANTIGENIC LINEAR PEPTIDE COMPOUNDS. | UNIV NORTHWESTERN (US) | 1983-12-23 | — | — | EP | disclosed |
| EP-0079934-A1 | ANTIGENIC LINEAR PEPTIDE COMPOUNDS. | UNIV NORTHWESTERN (US) | 1983-06-01 | — | — | EP | disclosed |
| WO-1982004250-A1 | ANTIGENIC LINEAR PEPTIDE COMPOUNDS | UNIV NORTHWESTERN (US) | 1982-12-09 | — | — | WO | disclosed |