Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15382436 | 0.89 | — | — | |
| SCHEMBL17527844 | 0.78 | EPHX1 (0.37) | EPHX1 | |
| SCHEMBL4590569 | 0.78 | THRB (0.36) | — | |
| SCHEMBL19619138 | 0.77 | SSTR4 (0.35) | EPHX1 | |
| SCHEMBL4589796 | 0.75 | — | — | |
| SCHEMBL29118786 | 0.73 | BTK (0.40) | BTKGAAEPHX1 | |
| SCHEMBL4471241 | 0.70 | KCNH2 (0.45) | EPHX1 | |
| SCHEMBL18658924 | 0.70 | EPHX2 (0.31) | — | |
| SCHEMBL4469273 | 0.70 | KCNH2 (0.45) | EPHX1 | |
| SCHEMBL18658867 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205564-A1 | NOVEL KINASE INHIBITORS | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009053269-A1 | NOVEL KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-30 | — | — | WO | disclosed |