Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GCG | P01275 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12165806 | 0.82 | LMNA (0.50) | RXFP1KDM4EL3MBTL1NPSR1SMN1; SMN2 | |
| SCHEMBL3654673 | 0.80 | KDM4E (0.43) | RXFP1KDM4EL3MBTL1NPSR1SMN1; SMN2 | |
| SCHEMBL3655710 | 0.75 | KDM4E (0.49) | RXFP1KDM4EL3MBTL1NPSR1SMN1; SMN2 | |
| SCHEMBL27929589 | 0.74 | KMT2A (0.43) | KDM4ENPSR1LMNAALDH1A1POLB | |
| SCHEMBL27979447 | 0.71 | MAPT (0.50) | KDM4ENPSR1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL27979450 | 0.70 | ALDH1A1 (0.56) | NPSR1LMNAALDH1A1HPGDMEN1 | |
| SCHEMBL24115263 | 0.70 | ALDH1A1 (0.57) | KDM4ELMNAALDH1A1HPGDPOLB | |
| SCHEMBL13593226 | 0.70 | ALDH1A1 (0.57) | KDM4ELMNAALDH1A1HPGDPOLB | |
| SCHEMBL4628700 | 0.69 | KMT2A (0.58) | L3MBTL1SMN1; SMN2LMNAALDH1A1MEN1 | |
| SCHEMBL10962850 | 0.69 | KMT2A (0.51) | KDM4EL3MBTL1SMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205602-A1 | IMIDAZOÝL,2- ¨QUINOXALINES AND DERIVATIVES THEREOF FOR TREATING CANCERS | Université de Montpellier I (FR) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009043934-A1 | IMIDAZO[L,2-α]QUINOXALINES AND DERIVATIVES THEREOF FOR TREATING CANCERS | UNIVERSITE DE MONTPELLIER I (FR) | 2009-04-09 | — | — | WO | disclosed |