Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | STS | P08842 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3655526 | 0.77 | AKT1 (0.51) | — | |
| SCHEMBL389415 | 0.76 | KIT (0.42) | MEN1KMT2ASTSDRD2HTT | |
| SCHEMBL1001879 | 0.75 | SMN1; SMN2 (0.57) | MEN1KMT2ASTSDRD2HTT | |
| SCHEMBL7018924 | 0.74 | F10 (0.46) | STS | |
| SCHEMBL391467 | 0.73 | KIT (0.46) | MEN1KMT2ASTSHTTSMN1; SMN2 | |
| SCHEMBL391466 | 0.73 | KIT (0.46) | MEN1KMT2ASTSHTTSMN1; SMN2 | |
| SCHEMBL3489718 | 0.73 | TSHR (0.45) | MEN1KMT2ASTSGHSRKDM1A | |
| SCHEMBL3650884 | 0.73 | AKT1 (0.52) | — | |
| SCHEMBL3654802 | 0.72 | AKT1 (0.49) | — | |
| SCHEMBL3649754 | 0.72 | MT-CO2 (0.43) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2201012-A1 | PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS | AstraZeneca AB (SE) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009047563-A1 | PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | WO | disclosed |