SCHEMBL3657247

SCHEMBL3657247

CC1=Cc2c(cccc2N(c2ccccc2)c2ccccc2)C1

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
APP P05067 1/20 0.35
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
MAPT P10636 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3664832 0.95 APP (0.33) APP
SCHEMBL3662992 0.85 HSP90AA1 (0.33)
SCHEMBL3768337 0.82
SCHEMBL3661618 0.81 HSP90AA1 (0.32)
SCHEMBL10053648 0.75 APP (0.34) APP
SCHEMBL2959612 0.71 APP (0.34) APP
SCHEMBL1827132 0.69 PDCD1 (0.39) ALDH1A1
SCHEMBL30229874 0.69 PDCD1 (0.39) ALDH1A1
SCHEMBL30477217 0.69 CYP2A6 (0.36) ALDH1A1CYP1A2CYP3A4TDP1
SCHEMBL4035804 0.69 CYP2A6 (0.36) ALDH1A1CYP1A2CYP3A4TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2220101-B1 TRANSITION METAL COMPOUNDS BASELL POLYOLEFINE GMBH (DE) 2018-09-19 EP disclosed
US-8207281-B2 Process for preparing transition metal compounds for olefins polymerization BASELL POLYOLEFINE GMBH (DE) 2012-06-26 US disclosed
US-8207281-B2 Process for preparing transition metal compounds for olefins polymerization BASELL POLYOLEFINE GMBH (DE) 2012-06-26 US disclosed
US-8207281-B2 Process for preparing transition metal compounds for olefins polymerization BASELL POLYOLEFINE GMBH (DE) 2012-06-26 US disclosed
US-20100311926-A1 PROCESS FOR PREPARING TRANSITION METAL COMPOUNDS FOR OLEFINS POLYMERIZATION BASELL POLYOLEFINE GMBH (DE) 2010-12-09 US disclosed
US-20100311926-A1 PROCESS FOR PREPARING TRANSITION METAL COMPOUNDS FOR OLEFINS POLYMERIZATION BASELL POLYOLEFINE GMBH (DE) 2010-12-09 US disclosed
US-20100311926-A1 PROCESS FOR PREPARING TRANSITION METAL COMPOUNDS FOR OLEFINS POLYMERIZATION BASELL POLYOLEFINE GMBH (DE) 2010-12-09 US disclosed
EP-2220101-A1 PROCESS FOR PREPARING TRANSITION METAL COMPOUNDS FOR OLEFIN POLYMERIZATION Basell Polyolefine GmbH (DE) 2010-08-25 EP disclosed
WO-2009077115-A1 PROCESS FOR PREPARING TRANSITION METAL COMPOUNDS FOR OLEFIN POLYMERIZATION BASELL POLYOLEFINE GMBH (DE) 2009-06-25 WO disclosed
WO-2009077115-A1 PROCESS FOR PREPARING TRANSITION METAL COMPOUNDS FOR OLEFIN POLYMERIZATION BASELL POLYOLEFINE GMBH (DE) 2009-06-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100311926-A1 PROCESS FOR PREPARING TRANSITION METAL COMPOUNDS FOR OLEFINS POLYMERIZATION FES, AP1S1, NBAS APP 1831/4885KDM4E 4403/4885ALDH1A1 2214/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.