NBAS — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4699731	1.00	2/20
SCHEMBL16111548	1.00	2/20
SCHEMBL29358745	1.00	2/20
SCHEMBL29380618	1.00	2/20
SCHEMBL29931136	1.00	2/20
SCHEMBL4697866	0.89	2/20
SCHEMBL24532075	0.89	2/20
SCHEMBL4697696	0.86	2/20
SCHEMBL23092285	0.86	2/20
SCHEMBL24532059	0.86	2/20
SCHEMBL29688472	0.86	2/20
SCHEMBL22024695	0.86	2/20
SCHEMBL16136600	0.84	2/20
SCHEMBL24532058	0.83	2/20
SCHEMBL4699947	0.83	2/20
SCHEMBL22025026	0.82	2/20
SCHEMBL22119546	0.82	2/20
SCHEMBL24532062	0.82	2/20
SCHEMBL18804561	0.81	2/20
SCHEMBL22024561	0.81	2/20

Clinical trials — most relevant to NBAS by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome	PHASE3	COMPLETED
A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study)	PHASE3	RECRUITING
Safety and Preliminary Efficacy of TSHA-102 Gene Therapy in Pediatric Females Aged >2 to <4 Years With Rett Syndrome	PHASE3	RECRUITING
PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS	PHASE2	COMPLETED
Pharmacological Treatment of Rett Syndrome With Glatiramer Acetate (Copaxone)	PHASE2	COMPLETED
5-azacytidine Valproic Acid and ATRA in AML and High Risk MDS	PHASE2	COMPLETED
An Open-Label Study of Oral NNZ-2591 in Pitt Hopkins Syndrome (PTHS-001)	PHASE2	COMPLETED
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)	PHASE1/PHASE2	RECRUITING
Treatment of Acute Myeloid Leukemia With Arsenic and All-trans Retinoid Acid	PHASE1	UNKNOWN
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants.	nan	UNKNOWN
Structural-functional Connectome in Drug-resistant Epilepsies and Neurodevelopmental Syndromes With Epilepsy	nan	RECRUITING
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Defining the Brain Phenotype of Children With Williams Syndrome	nan	RECRUITING
Testing of NBIA Genes: Analysis of Genetic Heterogeneity and Validation of Mitochondrial Markers for Assessing Causality of Sequence Variants.	nan	COMPLETED
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients	nan	RECRUITING
Neurological and Psychological Assessment of Neurocutaneous Syndromes in Upper Egypt Children	nan	UNKNOWN
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models	nan	COMPLETED
Genetic of Intellectual Deficiency and Autism Spectrum Disorders (RaDiCo-GenIDA)	nan	RECRUITING
NTRK 1,2,3 Rearrangements in Patients With Solid Tumors	nan	ACTIVE_NOT_RECRUITING
Study of a Candidate Gene Involved in Goldenhar Syndrome.	nan	COMPLETED
Genetics and Psychopathology in the 22q11 Deletion Syndrome	nan	UNKNOWN
The Rett Syndrome Global Registry	nan	RECRUITING
Thermogenic Silencer Regulatory Factors in Humans	nan	ACTIVE_NOT_RECRUITING
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
ScreenPlus: A Comprehensive, Flexible, Multi-disorder Newborn Screening Program	nan	ENROLLING_BY_INVITATION
Genomic Uniformed-Screening Against Rare Disease In All Newborns	nan	RECRUITING
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome	nan	ACTIVE_NOT_RECRUITING
A Retrospective Study to Determine the Incidence of NTRK Fusions. NTRK Study	nan	COMPLETED
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients	nan	RECRUITING
Efficacy and Safety of Radiofrequency Pallidotomy in the Management of Dystonia	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a NBAS binder may also engage these)

Protein	Name	Similarity
Q5TYW4	—	0.999	Q5TYW4 →
Q91VB4	—	0.997	Q91VB4 →
Q8WUM0	—	0.993	Q8WUM0 →
A0A2R8QPS5	—	0.993	A0A2R8QPS5 →
Q9Y3R5	—	0.993	Q9Y3R5 →
Q3UHQ6	—	0.992	Q3UHQ6 →
Q5ZLS8	—	0.992	Q5ZLS8 →
Q8C3Y4	—	0.992	Q8C3Y4 →
Q14D04	—	0.992	Q14D04 →
KNTC1	Kinetochore-associated protein 1	0.991	landscape →
O88480	—	0.991	O88480 →
Q8C456	—	0.991	Q8C456 →
Q5PQS3	—	0.991	Q5PQS3 →
B1WC10	—	0.991	B1WC10 →
GSAP	Gamma-secretase-activating protein	0.991	landscape →
Q32NR9	—	0.991	Q32NR9 →
Q5JWR5	—	0.991	Q5JWR5 →
Q9Z0W3	—	0.991	Q9Z0W3 →
Q6P2C0	—	0.990	Q6P2C0 →
O95876	—	0.990	O95876 →
Q969F9	—	0.990	Q969F9 →
Q7Z3E5	—	0.990	Q7Z3E5 →
Q5T0N1	—	0.990	Q5T0N1 →
Q6NTN5	—	0.990	Q6NTN5 →
Q2HJE1	—	0.990	Q2HJE1 →
Q9P2D8	—	0.990	Q9P2D8 →
Q96N23	—	0.989	Q96N23 →
Q5R6T6	—	0.989	Q5R6T6 →
A1A535	—	0.989	A1A535 →
A2CEI4	—	0.989	A2CEI4 →