Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.50 |
| ▸ | PRKACA | P17612 | 5/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.50 |
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 12/20 | 0.40 |
| ▸ | PIM1 | P11309 | 4/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.38 |
| ▸ | CHUK | O15111 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3960211 | 1.00 | ROCK2 (0.50) | ROCK2PRKACAROCK1DYRK1AMAP4K4 | |
| Phosphoric Acid SCHEMBL3956343 | 0.92 | ROCK2 (0.44) | ROCK2PRKACAROCK1DYRK1AMAP4K4 | |
| SCHEMBL4242133 | 0.87 | CHRNB2 (0.58) | ROCK2PRKACAROCK1DYRK1AMAP4K4 | |
| SCHEMBL4242134 | 0.87 | CHRNB2 (0.58) | ROCK2PRKACAROCK1DYRK1AMAP4K4 | |
| SCHEMBL4247313 | 0.86 | CHRNB2 (0.66) | ROCK2PRKACAROCK1DYRK1AMAP4K4 | |
| SCHEMBL1691835 | 0.86 | CHRNB2 (0.66) | ROCK2PRKACAROCK1DYRK1AMAP4K4 | |
| SCHEMBL3838406 | 0.85 | CHRNB2 (0.53) | ROCK2PRKACAROCK1DYRK1AMAP4K4 | |
| SCHEMBL7071079 | 0.83 | ROCK2 (0.50) | ROCK2PRKACAROCK1DYRK1AMAP4K4 | |
| SCHEMBL7071081 | 0.83 | ROCK2 (0.50) | ROCK2PRKACAROCK1DYRK1AMAP4K4 | |
| SCHEMBL7529713 | 0.82 | CHRNB2 (0.41) | ROCK2PRKACAROCK1DYRK1AMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009018367-A2 | NOVEL SALT FORMS OF (2S)-(4E)-N-METHYL-5-[3-(5-METHOXYPYRIDIN)YL]-4-PENTEN-2-AMINE | TARGACEPT, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| CN-103180277-A | New process for the preparation of aryl substituted olefinic amines | TARGACEPT INC | 2013-06-26 | — | — | CN | disclosed |
| EP-2574188-A1 | NEW PROCESS FOR THE PREPARATION OF ARYL SUBSTITUTED OLEFINIC AMINES | Targacept, Inc. (US) | 2013-04-03 | — | — | EP | disclosed |
| WO-2011146009-A8 | NEW PROCESS FOR THE PREPARATION OF ARYL SUBSTITUTED OLEFINIC AMINES | ASTRAZENECA AB (SE) | 2012-01-19 | — | — | WO | disclosed |
| WO-2011146009-A1 | NEW PROCESS FOR THE PREPARATION OF ARYL SUBSTITUTED OLEFINIC AMINES | TARGACEPT INC. (SE) | 2011-11-24 | — | — | WO | disclosed |
| EP-2112923-A1 | INTRANASAL, BUCCAL, AND SUBLINGUAL ADMINISTRATION OF METANICOTINE ANALOGS | Targacept Inc. (US) | 2009-11-04 | — | — | EP | disclosed |
| WO-2009018367-A2 | NOVEL SALT FORMS OF (2S)-(4E)-N-METHYL-5-[3-(5-METHOXYPYRIDIN)YL]-4-PENTEN-2-AMINE | TARGACEPT, INC. (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008091588-A1 | INTRANASAL, BUCCAL, AND SUBLINGUAL ADMINISTRATION OF METANICOTINE ANALOGS | TARGACEPT, INC. (US) | 2008-07-31 | — | — | WO | disclosed |
| WO-2008091592-A1 | INTRANASAL, BUCCAL, AND SUBLINGUAL ADMINISTRATION OF METANICOTINE ANALOGS | TARGACEPT, INC. (US) | 2008-07-31 | — | — | WO | disclosed |
| EP-1814852-A2 | HYDROXYBENZOATE SALTS OF METANICOTINE COMPOUNDS | Targacept, Inc. (US) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006053082-A2 | HYDROXYBENZOATE SALTS OF METANICOTINE COMPOUNDS | TARGACEPT, INC. (US) | 2006-05-18 | — | — | WO | disclosed |