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SCHEMBL3657693

SCHEMBL3657693

Cc1nc(-c2ccccc2)n2c1c(NS(=O)(=O)CN(c1nc3ccc(F)cc3n3c(-c4ccccc4Cl)nc(C)c13)S(C)(=O)=O)nc1ccc(F)cc12

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PDE2A O00408 18/20 0.42
▸ PDE10A Q9Y233 10/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3655166 0.81 PDE2A (0.58) PDE2APDE10A
SCHEMBL3658185 0.80 PDE10A (0.41) PDE2APDE10A
SCHEMBL3658809 0.78 PDE10A (0.54) PDE2APDE10A
SCHEMBL972787 0.72 PDE2A (0.77) PDE2APDE10A
SCHEMBL3657690 0.72 PDE2A (0.47) PDE2APDE10A
SCHEMBL969766 0.69 PDE2A (0.63) PDE2APDE10A
SCHEMBL970002 0.69 PDE10A (0.58) PDE2APDE10A
SCHEMBL970421 0.68 PDE10A (0.71) PDE2APDE10A
SCHEMBL3654538 0.65 ADORA3 (0.48) PDE2APDE10A
SCHEMBL3667895 0.65 PDE10A (0.46) PDE2APDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2227472-A1 ARYL AND HETEROARYL FUSED IMIDAZO (1,5-A) PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10 Elbion Gmbh (DE) 2010-09-15 — — EP disclosed
WO-2009068320-A1 ARYL AND HETEROARYL FUSED IMIDAZO (1,5-A) PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10 ELBION GMBH (DE) 2009-06-04 — — WO disclosed