Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 16/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1787671 | 0.96 | GHSR (0.60) | GHSRPOLBCHRNA4SLC6A3MEN1 | |
| SCHEMBL1788698 | 0.91 | GHSR (0.57) | GHSRPOLBCHRNA4SLC6A3MEN1 | |
| SCHEMBL1788643 | 0.91 | GHSR (0.66) | GHSRPOLBCHRNA4SLC6A3MEN1 | |
| SCHEMBL1787524 | 0.90 | GHSR (0.58) | GHSRPOLBCHRNA4SLC6A3MEN1 | |
| SCHEMBL2679282 | 0.87 | GHSR (0.64) | GHSRCHRNA4SLC6A3MEN1KMT2A | |
| SCHEMBL1785514 | 0.85 | GHSR (0.62) | GHSRPOLBCHRNA4SLC6A3MEN1 | |
| SCHEMBL1787721 | 0.85 | GHSR (0.66) | GHSRCHRNA4SLC6A3MEN1KMT2A | |
| SCHEMBL1785425 | 0.84 | GHSR (0.64) | GHSRPOLBCHRNA4SLC6A3MEN1 | |
| SCHEMBL1787370 | 0.83 | GHSR (0.60) | GHSRCHRNA4SLC6A3MEN1KMT2A | |
| SCHEMBL1785399 | 0.83 | GHSR (0.67) | GHSRCHRNA4SLC6A3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205576-A1 | BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2010-07-14 | — | — | EP | claimed |
| WO-2009047558-A1 | BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | WO | claimed |