Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 9/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 8/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 8/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968281 | 0.81 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL8302677 | 0.81 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| Hydrochloric Acid SCHEMBL6977239 | 0.80 | ADRA2A (0.56) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11190493 | 0.78 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL6964831 | 0.78 | ADRA2A (0.45) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL3711758 | 0.77 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL30357746 | 0.76 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL1741683 | 0.76 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CADRA1AADRA1D | |
| SCHEMBL11577556 | 0.72 | GLA (0.54) | GLAL3MBTL1LMNAMEN1CYP2D6 | |
| SCHEMBL11181667 | 0.71 | ADRA2A (0.56) | ADRA2AADRA2BADRA2CADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227464-A1 | DERIVATIVES OF 1-[(IMIDAZOLIDIN-2-YL)IMINO)]INDAZOLE | Imperial Innovations Limited (GB) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009071906-A1 | DERIVATIVES OF 1-[(IMIDAZOLIDIN-2-YL)IMINO)]INDAZOLE | IMPERIAL INNOVATIONS LIMITED (GB) | 2009-06-11 | — | — | WO | disclosed |