⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4977826 | 0.79 | — | — | |
| SCHEMBL14879590 | 0.79 | — | — | |
| SCHEMBL7158918 | 0.77 | ALDH1A1 (0.33) | — | |
| SCHEMBL7080083 | 0.71 | — | — | |
| SCHEMBL10476778 | 0.69 | — | — | |
| SCHEMBL436447 | 0.67 | ALDH1A1 (0.39) | — | |
| SCHEMBL9241042 | 0.63 | HSD17B10 (0.30) | — | |
| SCHEMBL25149017 | 0.62 | — | — | |
| SCHEMBL6040454 | 0.62 | — | — | |
| SCHEMBL9063389 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107722968-B | A kind of preparation method of the Ciprofloxacin ratio fluorescent probe based on nano-complex | 青岛大学 | 2019-07-16 | — | — | CN | claimed |
| US-9562014-B2 | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof | MALLINCKRODT LLC (US) | 2017-02-07 | — | — | US | claimed |
| US-20170029432-A1 | (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT ENTERPRISES LLC | 2017-02-02 | — | — | US | claimed |
| EP-2593095-A1 | (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | Mallinckrodt LLC (US) | 2013-05-22 | — | — | EP | claimed |
| WO-2012008984-A1 | (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2012-01-19 | — | — | WO | claimed |
| US-20110136845-A1 | (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof | MALLINCKRODT INC. (US) | 2011-06-09 | — | — | US | claimed |
| US-11142502-B2 | (+)-morphinans as antagonists of Toll-like receptor 9 and therapeutic uses thereof | MALLINCKRODT LLC (US) | 2021-10-12 | — | — | US | disclosed |
| US-20200172488-A1 | (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC | 2020-06-04 | — | — | US | disclosed |
| US-10604488-B2 | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof | MALLINCKRODT LLC (US) | 2020-03-31 | — | — | US | disclosed |
| US-10363251-B2 | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof | MALLINCKRODT LLC (US) | 2019-07-30 | — | — | US | disclosed |
| CN-107722968-B | A kind of preparation method of the Ciprofloxacin ratio fluorescent probe based on nano-complex | 青岛大学 | 2019-07-16 | — | — | CN | disclosed |
| EP-2593095-B1 | (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2019-03-27 | — | — | EP | disclosed |
| US-9562014-B2 | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof | MALLINCKRODT LLC (US) | 2017-02-07 | — | — | US | disclosed |
| EP-2593095-A1 | (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | Mallinckrodt LLC (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012008984-A1 | (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2012-01-19 | — | — | WO | disclosed |
| US-20110136845-A1 | (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof | MALLINCKRODT INC. (US) | 2011-06-09 | — | — | US | disclosed |
| EP-1689359-A2 | COMPOSITION FOR THE TREATMENT OF ARTHROSIS/ARTHRITIS, ESPECIALLY FOR TREATING JOINTS | Trott, Katharina (DE) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005039528-A2 | COMPOSITION FOR THE TREATMENT OF ARTHROSIS/ARTHRITIS, ESPECIALLY FOR TREATING JOINTS | BESCHORNER KATHARINA (DE) | 2005-05-06 | — | — | WO | disclosed |
| EP-0693080-A1 | NEW GLUCOCORTICOIDS | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-01-24 | — | — | EP | disclosed |
| WO-1994022898-A1 | NEW GLUCOCORTICOIDS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-10-13 | — | — | WO | disclosed |