Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.34 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PKLR | P30613 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656718 | 0.80 | PARP1 (0.40) | GAASMN1; SMN2CYP2A6PDE3BPDE3A | |
| SCHEMBL3654190 | 0.77 | RAB9A (0.39) | TP53SMN1; SMN2CYP2A6PDE3BPDE3A | |
| SCHEMBL21195921 | 0.74 | PDGFRB (0.49) | MAPTPDGFRBPDGFRACYP2A6CYP2E1 | |
| SCHEMBL3658434 | 0.73 | ATM (0.39) | GAAMAPTSMN1; SMN2PDE3BPDE3A | |
| SCHEMBL1880359 | 0.71 | KDR (0.48) | GAAMAPTTP53SMN1; SMN2KDR | |
| SCHEMBL3747239 | 0.68 | DRD4 (0.37) | GAAMAPTTP53KDRCYP2A6 | |
| SCHEMBL2987897 | 0.68 | ALDH1A1 (0.38) | GAAMAPTCYP2A6PDE3BPDE3A | |
| SCHEMBL1885110 | 0.68 | GPBAR1 (0.42) | GAAMAPTTP53SMN1; SMN2KDR | |
| SCHEMBL1878979 | 0.68 | MEN1 (0.43) | GAAMAPTTP53SMN1; SMN2KDR | |
| SCHEMBL3656854 | 0.68 | BRD4 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231641-A2 | QUINOXALINE AND QUINOLINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009081105-A2 | QUINOXALINE AND QUINOLINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2009-07-02 | — | — | WO | disclosed |