Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 11/20 | 0.45 |
| ▸ | CA1 | P00915 | 10/20 | 0.45 |
| ▸ | CA9 | Q16790 | 5/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27702233 | 0.76 | CA2 (0.47) | CA2CA1CA9LMNACA12 | |
| SCHEMBL4636702 | 0.70 | CA1 (0.37) | CA2CA1CA9LMNACA12 | |
| SCHEMBL6873689 | 0.70 | POLQ (0.53) | KDM4EALDH1A1 | |
| SCHEMBL29907879 | 0.70 | POLQ (0.53) | KDM4EALDH1A1 | |
| SCHEMBL2512044 | 0.70 | CA2 (0.46) | CA2CA1CA9LMNACA12 | |
| SCHEMBL20504959 | 0.70 | CA2 (0.42) | CA2CA1CA9LMNACA12 | |
| SCHEMBL17698980 | 0.70 | PTGES2 (0.45) | CA2CA1CA9LMNACA12 | |
| SCHEMBL31016094 | 0.68 | CA1 (0.42) | CA2CA1CA9LMNAKDM4E | |
| SCHEMBL5738109 | 0.68 | AKR1B1 (0.61) | CA2CA1CA9KDM4ECA12 | |
| SCHEMBL966585 | 0.67 | MEN1 (0.45) | CA2CA1LMNAP2RX7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205556-A2 | BIARYL SULFONAMIDE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009040289-A2 | BIARYL SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-02 | — | — | WO | disclosed |