Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 5/20 | 0.68 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.68 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.68 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.48 |
| ▸ | OGA | O60502 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | BLK | P51451 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3562692 | 0.86 | MAPK10 (0.67) | MAPK10MAPK9MAPK8MKNK1MKNK2 | |
| SCHEMBL3574117 | 0.84 | MAPK10 (0.52) | MAPK10MAPK9MAPK8MKNK1MKNK2 | |
| SCHEMBL3562691 | 0.84 | MAPK10 (0.52) | MAPK10MAPK9MAPK8MKNK1MKNK2 | |
| SCHEMBL3572139 | 0.83 | MAPK10 (0.48) | MAPK10MAPK9MAPK8OGAKDM4E | |
| SCHEMBL3575426 | 0.82 | MAPK8 (0.50) | MAPK10MAPK9MAPK8MKNK1MKNK2 | |
| SCHEMBL29432586 | 0.81 | MAPK10 (1.00) | MAPK10MAPK9MAPK8MKNK1MKNK2 | |
| SCHEMBL21067982 | 0.81 | MAPK10 (1.00) | MAPK10MAPK9MAPK8MKNK1MKNK2 | |
| SCHEMBL5618538 | 0.81 | MAPK10 (0.66) | MAPK10MAPK9MAPK8MKNK1MKNK2 | |
| SCHEMBL186278 | 0.81 | MAPK10 (1.00) | MAPK10MAPK9MAPK8MKNK1MKNK2 | |
| SCHEMBL3569491 | 0.80 | MAPK8 (0.46) | MAPK10MAPK9MAPK8MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633363-B1 | PYRIDINYL ACETONITRILES | MERCK SERONO SA (CH) | 2012-11-07 | — | — | EP | claimed |
| US-7855212-B2 | Pyridinyl acetonitriles | MERCK SERONO SA (CH) | 2010-12-21 | — | — | US | claimed |