Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SGK1 | O00141 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3659104 | 0.82 | MAPK10 (0.68) | MAPK8MAPK9MAPK10CYP1A2CYP2D6 | |
| SCHEMBL3562691 | 0.80 | MAPK10 (0.52) | MAPK8MAPK9MAPK10CYP1A2CYP2D6 | |
| SCHEMBL3569491 | 0.75 | MAPK8 (0.46) | MAPK8MAPK9MAPK10CYP1A2CYP2D6 | |
| SCHEMBL3574117 | 0.71 | MAPK10 (0.52) | MAPK8MAPK9MAPK10OGAMKNK1 | |
| SCHEMBL3562692 | 0.70 | MAPK10 (0.67) | MAPK8MAPK9MAPK10OGAMKNK1 | |
| SCHEMBL3566255 | 0.67 | ALDH1A1 (0.41) | MAPK8MAPK9MAPK10CYP1A2OGA | |
| SCHEMBL14869419 | 0.67 | APP (0.65) | L3MBTL1KCNH3ADORA1CA1CA2 | |
| SCHEMBL3572139 | 0.67 | MAPK10 (0.48) | MAPK8MAPK9MAPK10CYP1A2OGA | |
| SCHEMBL3562914 | 0.67 | MAPK8 (0.37) | MAPK8MAPK9MAPK10CYP1A2CYP2D6 | |
| SCHEMBL21067982 | 0.67 | MAPK10 (1.00) | MAPK8MAPK9MAPK10OGAMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633363-B1 | PYRIDINYL ACETONITRILES | MERCK SERONO SA (CH) | 2012-11-07 | — | — | EP | disclosed |
| US-7855212-B2 | Pyridinyl acetonitriles | MERCK SERONO SA (CH) | 2010-12-21 | — | — | US | disclosed |
| US-20070060594-A1 | Pyridinyl acetonitriles | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060594-A1 | Pyridinyl acetonitriles | GSK3B, GSK3A, MAPK3 | MAPK8 31/4885MAPK9 105/4885MAPK10 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.