Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.88 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL37496 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL600583 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL372189 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL372671 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL372535 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL8146438 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL13684439 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL20917177 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL21753855 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL372698 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4404916-B1 | AN IMPROVED PHARMACEUTICAL COMPOSITION FOR NASAL USE, PREPARATION, AND USE THEREOF | JADRAN GALENSKI LABORATORIJ D D (HR) | 2025-08-06 | — | — | EP | claimed |
| CN-118872659-A | Livestock semen low-temperature preservation solution and preparation method and application thereof | 西南科技大学 | 2024-11-01 | — | — | CN | claimed |
| EP-4404916-A1 | AN IMPROVED PHARMACEUTICAL COMPOSITION FOR NASAL USE, PREPARATION, AND USE THEREOF | JADRAN - GALENSKI LABORATORIJ d.d. (HR) | 2024-07-31 | — | — | EP | claimed |
| CN-114235911-B | Electrochemical sensor for choline detection and preparation method thereof | 重庆大学 | 2024-07-23 | — | — | CN | claimed |
| CN-117904256-A | Excrement sample preservation solution and preparation method and application thereof | 武汉友芝友医疗科技股份有限公司 | 2024-04-19 | — | — | CN | claimed |
| CN-117825477-A | Cuprous oxide nanometer microsphere sensor based on molecular imprinting technology and preparation method | 北方华锦化学工业股份有限公司 | 2024-04-05 | — | — | CN | claimed |
| CN-117126644-A | FeCo/Fe 2 O 3 Composite wave-absorbing material of/C fiber, preparation method and application thereof | 中原工学院 | 2023-11-28 | — | — | CN | claimed |
| CN-117050151-A | Mycoplasma synoviae rMSPB truncated protein and MS antibody ELISA detection kit and application | 西北农林科技大学 | 2023-11-14 | — | — | CN | claimed |
| CN-114735672-B | Boron-nitrogen co-doped hard carbon material and preparation method thereof | 深圳市科信通信技术股份有限公司 | 2023-08-25 | — | — | CN | claimed |
| CN-116334686-B | Ruthenium nitrogen doped carbon coated copper-cobalt alloy nano-catalyst and preparation method thereof | 中石油深圳新能源研究院有限公司 | 2023-07-28 | — | — | CN | claimed |
| CN-113975389-B | Macrophage-loaded multifunctional mesoporous ferric oxide nano diagnosis and treatment preparation, preparation method thereof and anti-tumor application | 中山大学孙逸仙纪念医院 | 2023-07-18 | — | — | CN | claimed |
| CN-116376643-A | Protein cleaning agent and preparation method and application thereof | 江苏三联生物工程股份有限公司 | 2023-07-04 | — | — | CN | claimed |
| CN-116334686-A | Ruthenium nitrogen doped carbon coated copper-cobalt alloy nano-catalyst and preparation method thereof | 中石油深圳新能源研究院有限公司 | 2023-06-27 | — | — | CN | claimed |
| WO-2023078574-A1 | A PHARMACEUTICAL KIT FOR ONCOLYTIC VIROTHERAPY OF BREAST CANCER, ITS PREPARATION AND USE | SVEUCILISTE U ZAGREBU (HR) | 2023-05-11 | — | — | WO | claimed |
| WO-2023046590-A1 | AN IMPROVED PHARMACEUTICAL COMPOSITION FOR NASAL USE, PREPARATION, AND USE THEREOF | JADRAN - GALENSKI LABORATORIJ D.D. (HR) | 2023-03-30 | — | — | WO | claimed |
| CN-111021046-A | Similar-item chain-shaped MoS2/SnO2Preparation method of/CNF multifunctional composite interface material | 湖北大学 | 2020-04-17 | — | — | CN | claimed |
| CN-102380371-A | Preparation method of direct methanol fuel cell anode catalyst | UNIV NANCHANG | 2012-03-21 | — | — | CN | claimed |
| CN-121016774-B | Cobalt-bismuth bimetal regulated lead-based catalyst, preparation method and application thereof | 西北工业大学 | 2026-01-23 | — | — | CN | disclosed |
| WO-1992009680-A1 | NONPHOSPHATED DISHWASHING COMPOSITIONS WITH OXYGEN BLEACH SYSTEMS | THE PROCTER & GAMBLE COMPANY (US) | 1992-06-11 | — | — | WO | disclosed |
| EP-0271838-A2 | Novel microorganisms capable of assimilating lactose | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1988-06-22 | — | — | EP | disclosed |