Citric Acid

Citric Acid

SCHEMBL37496

O.O.O=C(O)CC(O)(CC(=O)O)C(=O)O.[NaH]

nearest known ligand 0.88

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.40
ALDH1A1 P00352 2/20 0.88
HMGCR P04035 1/20 0.46
CHRM1 P11229 1/20 0.46
TBXA2R P21731 1/20 0.46
ADRA1A P35348 1/20 0.46
TSHR P16473 2/20 0.43
CYP2D6 P10635 2/20 0.43
CYP2C19 P33261 1/20 0.43
HIF1A Q16665 1/20 0.43
ACLY P53396 4/20 0.42
KDM4E B2RXH2 2/20 0.42
LMNA P02545 2/20 0.42
MAPT P10636 1/20 0.42
ALOX15 P16050 1/20 0.42
SLC13A5 Q86YT5 4/20 0.41
CPT2 P23786 1/20 0.41
CYP1A2 P05177 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL365960 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL600583 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL372189 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL372671 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL372535 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL8146438 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL13684439 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL20917177 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL21753855 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL372698 1.00 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 16645 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12636412-B2 Coating composition for skin-contacting surface of elastomeric articles and articles containing the same ALLEGIANCE CORPORATION (US) 2026-05-26 US claimed
CN-122075409-A External preparation for treating herpes and skin injury and preparation method thereof 2026-05-26 CN claimed
CN-121587410-B Low-salt thick broad-bean sauce production process based on synergistic fermentation of composite strains Sichuan Dandan Pixian Bean Paste Group Co.,Ltd. (CN) 2026-05-26 CN claimed
CN-122084792-A Method for detecting residues of iso Ding Yiyang quinoline and metabolites thereof in plant-derived food 2026-05-26 CN claimed
CN-122071418-A Preparation method of salbutamol sulfate, salbutamol sulfate injection and preparation method of salbutamol sulfate injection 海南皇隆制药股份有限公司 2026-05-22 CN claimed
WO-2026103397-A1 COMPOSITE ELECTROMAGNETIC WAVE-ABSORBING MATERIAL PREPARATION METHOD, COMPOSITE ELECTROMAGNETIC WAVE-ABSORBING MATERIAL, AND RAIL VEHICLE 中车唐山机车车辆有限公司 2026-05-21 WO claimed
CN-122060656-A Engineering strain for efficiently producing ectoin by polysaccharide co-utilization and fermentation process 南京工业大学 2026-05-19 CN claimed
CN-122060620-A Lactobacillus plantarum microbial preparation and preparation method and application thereof 乐山恒峰华邦生物科技有限公司 2026-05-19 CN claimed
WO-2026098542-A1 PHARMACEUTICAL FORMULATIONS OF CURCUMIN AND/OR RESVERATROL COMPOUNDS CALIWAY BIOPHARMACEUTICALS CO., LTD. (CN) 2026-05-15 WO claimed
US-20260130870-A1 PHENYLEPHRINE LIQUID FORMULATIONS FRESENIUS KABI AUSTRIA GMBH (AT) 2026-05-14 US claimed
EP-0019054-B1 NUTRIENT MEDIUM AND ITS USE IN TESTING ANTIMICROBIAL AGENTS F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1982-05-05 EP claimed
US-4275154-A Nutrient medium HOFFMANN-LA ROCHE INC. (US) 1981-06-23 US claimed
US-4260528-A GUMS, ALCOHOLS, UREA LEVER BROTHERS COMPANY (US) 1981-04-07 US claimed
EP-0019054-A1 Nutrient medium and its use in testing antimicrobial agents F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1980-11-26 EP claimed
US-4102400-A CEMENTING A WELL, PRETREATMENT WITH ALKALI METAL SILICATE AND CELLULOSE COMPOUND THE DOW CHEMICAL COMPANY (US) 1978-07-25 US claimed
US-4083407-A WATER, ALKALI METAL SILICATE, METAL COMPOUND AS A GELLING AGENT, CELLULOSE COMPOUND, INERT PARTICULATE MATERIAL THE DOW CHEMICAL COMPANY (US) 1978-04-11 US claimed
US-4025654-A SODIUM SALT, ANTIBIOTIC ABBOTT LABORATORIES (US) 1977-05-24 US claimed
US-4013577-A POLYETHER SULFATE, NON-PHOSPHATE BUILDERS COLGATE-PALMOLIVE COMPANY (US) 1977-03-22 US claimed
US-4009114-A ALKYL ARYL SULFONATES, ALKALI METAL SILICATES AND CARBONATES COLGATE-PALMOLIVE COMPANY (US) 1977-02-22 US claimed
US-3962106-A DETERGENTS LEVER BROTHERS COMPANY (US) 1976-06-08 US claimed