Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.67 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6014110 | 0.86 | MCHR1 (0.66) | DRD2ABCG2KMT2AMCHR2MCHR1 | |
| SCHEMBL5470744 | 0.86 | ABCG2 (0.68) | DRD2ABCG2KMT2A | |
| SCHEMBL4572920 | 0.84 | DRD2 (0.60) | DRD2ABCG2RAB9AKMT2AMCHR2 | |
| SCHEMBL4341169 | 0.83 | MCHR1 (0.69) | DRD2ABCG2RAB9AKMT2AMCHR2 | |
| SCHEMBL17790224 | 0.81 | ROCK2 (0.61) | DRD2ABCG2KMT2A | |
| SCHEMBL13060675 | 0.81 | ABCG2 (0.62) | DRD2ABCG2KMT2A | |
| SCHEMBL13060816 | 0.81 | ABCG2 (0.62) | DRD2ABCG2KMT2A | |
| SCHEMBL18376289 | 0.81 | MAPT (0.73) | DRD2ABCG2RAB9AKMT2AMCHR2 | |
| SCHEMBL15514290 | 0.81 | DRD2 (1.00) | DRD2 | |
| SCHEMBL15514289 | 0.81 | DRD2 (1.00) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212326-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009024824-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |