Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.39 |
| ▸ | CTSC | P53634 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12383351 | 0.80 | CTSC (0.53) | GPR119CTSC | |
| SCHEMBL8035656 | 0.80 | GPR119 (0.47) | GPR119USP30CTSCUCHL1MEN1 | |
| SCHEMBL2075087 | 0.79 | VHL (0.49) | GPR119USP30CTSCMEN1KMT2A | |
| SCHEMBL2075088 | 0.79 | VHL (0.49) | GPR119USP30CTSCMEN1KMT2A | |
| SCHEMBL27950459 | 0.68 | GPR119 (0.48) | GPR119USP30UCHL1MEN1KMT2A | |
| SCHEMBL30280823 | 0.68 | GPR119 (0.48) | GPR119USP30UCHL1MEN1KMT2A | |
| SCHEMBL2074295 | 0.67 | CTSC (0.59) | CTSC | |
| SCHEMBL2072370 | 0.66 | CTSC (0.47) | CTSC | |
| SCHEMBL2072367 | 0.66 | CTSC (0.47) | CTSC | |
| SCHEMBL2075366 | 0.66 | VHL (0.54) | CTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231597-A1 | PEPTIDYL NITRILES AND USE THEREOF AS DIPEPTIDYL PEPTIDASE I INHIBITORS | AstraZeneca AB (SE) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009074829-A1 | PEPTIDYL NITRILES AND USE THEREOF AS DIPEPTIDYL PEPTIDASE I INHIBITORS | ASTRAZENECA AB (SE) | 2009-06-18 | — | — | WO | disclosed |