Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 12/20 | 0.40 |
| ▸ | P2RX2 | Q9UBL9 | 12/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664334 | 0.84 | P2RX3 (0.52) | P2RX3P2RX2 | |
| SCHEMBL3660665 | 0.83 | P2RX3 (0.59) | P2RX3P2RX2 | |
| SCHEMBL3659404 | 0.83 | P2RX3 (0.43) | P2RX3P2RX2 | |
| SCHEMBL3660190 | 0.82 | P2RX3 (0.60) | P2RX3P2RX2 | |
| SCHEMBL4163451 | 0.82 | P2RX3 (0.58) | P2RX3P2RX2 | |
| SCHEMBL3658272 | 0.81 | P2RY14 (0.38) | P2RX3P2RX2 | |
| SCHEMBL3663110 | 0.80 | P2RX3 (0.39) | P2RX3P2RX2 | |
| SCHEMBL27846532 | 0.79 | P2RX3 (0.56) | P2RX3P2RX2 | |
| SCHEMBL3659401 | 0.79 | P2RX3 (0.56) | P2RX3P2RX2 | |
| SCHEMBL3663118 | 0.77 | P2RX3 (0.37) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234976-A1 | NOVEL PYRAZOLE-SUBSTITUTED ARYLAMIDES | F. Hoffmann-La Roche AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009077367-A1 | NOVEL PYRAZOLE-SUBSTITUTED ARYLAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |