Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | JAK3 | P52333 | 4/20 | 0.49 |
| ▸ | IKBKB | O14920 | 3/20 | 0.48 |
| ▸ | CHUK | O15111 | 2/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308779 | 0.92 | PIK3CA (0.49) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL8311018 | 0.89 | JAK2 (0.61) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL3049760 | 0.88 | SYK (0.51) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL14021629 | 0.88 | JAK2 (0.54) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL4392408 | 0.88 | PIK3CA (0.51) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL14021222 | 0.87 | PIK3CA (0.53) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL14021327 | 0.87 | JAK2 (0.49) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL13590765 | 0.87 | JAK2 (0.51) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL14063782 | 0.87 | JAK2 (0.52) | PIK3CAPIK3CBPIK3CGJAK2JAK3 | |
| SCHEMBL14063828 | 0.86 | CAMK2D (0.61) | PIK3CAPIK3CBPIK3CGJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2157975-A2 | TREATMENT FOR NON-ALCOHOLIC-STEATOHEPATITIS | Ares Trading S.A. (CH) | 2010-03-03 | — | — | EP | claimed |
| EP-1931322-A1 | IKK INHIBITORS FOR THE TREATMENT OF ENDOMETRIOSIS | Laboratoires Serono SA (CH) | 2008-06-18 | — | — | EP | claimed |
| WO-2008040548-A2 | TREATMENT FOR NON-ALCOHOLIC-STEATOHEPATITIS | ARES TRADING S.A. (CH) | 2008-04-10 | — | — | WO | claimed |
| WO-2007030362-A1 | IKK INHIBITORS FOR THE TREATMENT OF ENDOMETRIOSIS | LABORATOIRES SERONO SA. (CH) | 2007-03-15 | — | — | WO | claimed |
| EP-2157975-A2 | TREATMENT FOR NON-ALCOHOLIC-STEATOHEPATITIS | Ares Trading S.A. (CH) | 2010-03-03 | — | — | EP | disclosed |
| EP-2139482-A1 | TREATMENT FOR MULTIPLE MYELOMA | Ares Trading S.A. (CH) | 2010-01-06 | — | — | EP | disclosed |
| EP-2037897-A2 | AN ORAL PHARMACEUTICAL COMPOSITION OF AN ANILINOPYRIMIDINE, ITS PREPARATION AND USE THEREOF | Ares Trading S.A. (CH) | 2009-03-25 | — | — | EP | disclosed |
| EP-1931322-A1 | IKK INHIBITORS FOR THE TREATMENT OF ENDOMETRIOSIS | Laboratoires Serono SA (CH) | 2008-06-18 | — | — | EP | disclosed |
| WO-2008064866-A1 | TREATMENT FOR MULTIPLE MYELOMA | ARES TRADING S.A. (CH) | 2008-06-05 | — | — | WO | disclosed |
| WO-2008040548-A2 | TREATMENT FOR NON-ALCOHOLIC-STEATOHEPATITIS | ARES TRADING S.A. (CH) | 2008-04-10 | — | — | WO | disclosed |
| WO-2008003769-A2 | AN ORAL PHARMACEUTICAL COMPOSITION OF AN ANILINOPYRIMIDINE, ITS PREPARATION AND USE THEREOF | ARES TRADING S.A. (CH) | 2008-01-10 | — | — | WO | disclosed |
| EP-1827422-A2 | JNK INHIBITORS FOR THE TREATMENT OF CNS INJURY | CELGENE CORPORATION (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2007030362-A1 | IKK INHIBITORS FOR THE TREATMENT OF ENDOMETRIOSIS | LABORATOIRES SERONO SA. (CH) | 2007-03-15 | — | — | WO | disclosed |
| WO-2006058007-A2 | JNK INHIBITORS FOR TREATMENT OF CNS INJURY | CELGENE CORPORATION (US) | 2006-06-01 | — | — | WO | disclosed |