Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | FASN | P49327 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3658942 | 0.93 | KDM4E (0.45) | KDM4EMEN1MAPTKMT2APARP1 | |
| SCHEMBL29490978 | 0.86 | KDM4E (0.50) | KDM4EMEN1MAPTKMT2AFASN | |
| SCHEMBL8335954 | 0.80 | MAPT (0.44) | KDM4EMEN1MAPTKMT2ATAS1R3 | |
| SCHEMBL11806074 | 0.79 | ACMSD (0.53) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL30868260 | 0.79 | MEN1 (0.50) | KDM4EMEN1MAPTKMT2AFASN | |
| SCHEMBL4598601 | 0.79 | KDM4E (0.45) | KDM4EMEN1MAPTKMT2APARP1 | |
| SCHEMBL1667824 | 0.78 | PTGDR2 (0.51) | KDM4EMEN1MAPTKMT2APARP1 | |
| SCHEMBL12505499 | 0.77 | KDM4E (0.51) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL3376199 | 0.77 | ADRA1A (0.49) | KDM4EMEN1MAPTKMT2APARP1 | |
| SCHEMBL28182422 | 0.74 | OPRL1 (0.43) | KDM4EMEN1MAPTKMT2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234995-A1 | LEUKOTRIENE B4 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009077385-A1 | LEUKOTRIENE B4 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |