Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 6/20 | 0.46 |
| ▸ | CA12 | O43570 | 5/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | G6PD | P11413 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.44 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365427 | 0.86 | ALDH1A1 (0.48) | CA9CA12CA1CA2KDM4E | |
| SCHEMBL366103 | 0.81 | ALDH1A1 (0.60) | CA9CA12CA2KDM4EALDH1A1 | |
| SCHEMBL364761 | 0.81 | KDM4E (0.52) | CA9CA12CA1CA2KDM4E | |
| SCHEMBL365648 | 0.81 | CA9 (0.45) | CA9CA12CA1CA2CYP1A2 | |
| SCHEMBL366460 | 0.80 | KDM4E (0.46) | KDM4EALDH1A1MEN1KMT2AAPAF1 | |
| SCHEMBL364969 | 0.79 | KDM4E (0.53) | KDM4EALDH1A1MEN1KMT2AAPAF1 | |
| SCHEMBL364770 | 0.79 | ELANE (0.48) | KDM4EALDH1A1MEN1KMT2AAPAF1 | |
| SCHEMBL365010 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1MEN1KMT2AAPAF1 | |
| SCHEMBL366638 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1MEN1KMT2AAPAF1 | |
| SCHEMBL367142 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1MEN1KMT2AAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |