Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | HPN | P05981 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661109 | 0.93 | MAPT (0.43) | MAPTRAB9ANPC1TSHRPOLB | |
| SCHEMBL3659618 | 0.90 | GAA (0.50) | MAPTRAB9ANPC1TSHRPOLB | |
| SCHEMBL3661087 | 0.83 | NPSR1 (0.48) | MAPTRAB9ANPC1TSHRPOLB | |
| SCHEMBL3653916 | 0.79 | NR1H4 (0.45) | MAPTTSHRLMNATP53GAA | |
| SCHEMBL3650056 | 0.78 | ALDH1A1 (0.48) | MAPTRAB9ANPC1POLBALDH1A1 | |
| SCHEMBL2305802 | 0.77 | TSHR (0.46) | MAPTRAB9ANPC1TSHRPOLB | |
| SCHEMBL3656516 | 0.77 | NR1H4 (0.46) | MAPTTSHRLMNATP53GAA | |
| SCHEMBL3655866 | 0.77 | NPC1 (0.38) | MAPTRAB9ANPC1POLBALDH1A1 | |
| SCHEMBL3652179 | 0.76 | NR1H4 (0.53) | MAPTRAB9ANPC1ALDH1A1PLAU | |
| SCHEMBL1843552 | 0.75 | TSHR (0.39) | MAPTTSHRPOLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225221-A2 | CARBOXYL- OR HYDROXYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009080555-A2 | CARBOXYL- OR HYDROXYL- SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-02 | — | — | WO | disclosed |