Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.59 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.54 |
| ▸ | MMP1 | P03956 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | MMP13 | P45452 | 2/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1994180 | 0.78 | SIGMAR1 (0.61) | POLBSIGMAR1OPRL1ALDH1A1MEN1 | |
| SCHEMBL6795896 | 0.78 | POLB (0.96) | SMN1; SMN2POLBSIGMAR1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL15608841 | 0.77 | CYP3A4 (0.59) | POLBSIGMAR1OPRL1ALDH1A1MEN1 | |
| SCHEMBL13202506 | 0.77 | SIGMAR1 (0.73) | SMN1; SMN2POLBSIGMAR1CYP1A2CYP2D6 | |
| Ammonia Solution, Strong SCHEMBL27704870 | 0.77 | CYP3A4 (0.59) | POLBSIGMAR1OPRL1ALDH1A1MEN1 | |
| SCHEMBL24023501 | 0.76 | POLB (1.00) | SMN1; SMN2POLBSIGMAR1KDM4EALDH1A1 | |
| SCHEMBL13293705 | 0.76 | POLB (1.00) | SMN1; SMN2POLBSIGMAR1KDM4EALDH1A1 | |
| SCHEMBL30596563 | 0.76 | POLB (1.00) | SMN1; SMN2POLBSIGMAR1KDM4EALDH1A1 | |
| SCHEMBL24023500 | 0.76 | POLB (1.00) | SMN1; SMN2POLBSIGMAR1KDM4EALDH1A1 | |
| SCHEMBL20868550 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2POLBSIGMAR1OPRL1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110319424-A1 | NAPHTHYRIDIN-2(1H) -ONE COMPOUNDS USEFUL AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2011-12-29 | — | — | US | disclosed |
| EP-2238135-A1 | NAPHTHYRIDIN-2(1H) -ONE COMPOUNDS USEFUL AS ANTIBACTERIALS | Glaxo Group Limited (GB) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009090222-A1 | NAPHTHYRIDIN-2(1H) -ONE COMPOUNDS USEFUL AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2009-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319424-A1 | NAPHTHYRIDIN-2(1H) -ONE COMPOUNDS USEFUL AS ANTIBACTERIALS | RIF1, MRPL21, NAT1 | SMN1; SMN2 3514/4885POLB 954/4885SIGMAR1 1314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.