Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | DOCK5 | Q9H7D0 | 1/20 | 0.43 |
| ▸ | GPR183 | P32249 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20868074 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBSIGMAR1OPRL1MAPT | |
| SCHEMBL20868155 | 0.80 | L3MBTL1 (0.51) | POLBSIGMAR1OPRL1FAAHKCNH2 | |
| SCHEMBL1290790 | 0.80 | OPRL1 (0.58) | POLBSIGMAR1OPRL1ALDH1A1MEN1 | |
| SCHEMBL23230047 | 0.77 | ALDH1A1 (0.44) | SMN1; SMN2HTTALDH1A1OPRM1 | |
| SCHEMBL632458 | 0.76 | POLB (0.49) | SMN1; SMN2POLBSIGMAR1OPRL1HTT | |
| SCHEMBL3661082 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2POLBSIGMAR1OPRL1HTT | |
| SCHEMBL6795896 | 0.76 | POLB (0.96) | SMN1; SMN2POLBSIGMAR1HTTKDM4E | |
| SCHEMBL20697810 | 0.75 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBSIGMAR1OPRL1HTT | |
| SCHEMBL20868522 | 0.74 | ATM (0.56) | SMN1; SMN2POLBMAPTKDM4EALDH1A1 | |
| SCHEMBL24023500 | 0.74 | POLB (1.00) | SMN1; SMN2POLBSIGMAR1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019062848-A1 | N-(SUBSTITUTED SULFONYL)BENZAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 浙江海正药业股份有限公司 | 2019-04-04 | — | — | WO | disclosed |