Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 11/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.42 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LPL | P06858 | 1/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664292 | 0.89 | SLC6A5 (0.46) | PRKAA2SCN1ASCN5ASCN9AEPHX2 | |
| SCHEMBL4427569 | 0.85 | HRH3 (0.51) | SCN1ASCN5ASCN9AEPHX2SLC6A5 | |
| SCHEMBL2505772 | 0.85 | SLC6A5 (0.60) | PRKAA2SLC6A5PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL3664140 | 0.85 | HPGDS (0.42) | PRKAA2SCN1ASCN5ASCN9AEPHX2 | |
| SCHEMBL3663685 | 0.84 | HRH3 (0.52) | SCN1ASCN5ASCN9AEPHX2SLC6A5 | |
| SCHEMBL4431231 | 0.84 | SCN9A (0.46) | SCN1ASCN5ASCN9AEPHX2SLC6A5 | |
| SCHEMBL647131 | 0.83 | SLC6A5 (0.51) | PRKAA2SCN1ASCN5ASCN9ASLC6A5 | |
| SCHEMBL3668147 | 0.82 | PRKAA2 (0.49) | PRKAA2SCN9AEPHX2FFAR1LPL | |
| SCHEMBL3663733 | 0.81 | SLC6A4 (0.43) | SCN1ASCN5ASCN9AEPHX2FFAR1 | |
| SCHEMBL648104 | 0.80 | SLC6A5 (0.53) | PRKAA2SLC6A5TEAD1PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |