Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASH1L | Q9NR48 | 4/20 | 0.74 |
| ▸ | PRKCI | P41743 | 1/20 | 0.63 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.50 |
| ▸ | HPGDS | O60760 | 2/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CCNH | P51946 | 1/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | DHPS | P49366 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6319628 | 0.86 | ASH1L (0.67) | ASH1LPRKCIPIK3CDHPGDSPIK3CB | |
| SCHEMBL30593676 | 0.85 | ASH1L (1.00) | ASH1LPIK3CDPIK3CBCSNK2BCSNK2A1 | |
| SCHEMBL21004055 | 0.85 | ASH1L (0.74) | ASH1LPRKCIBRD4PIK3CDHPGDS | |
| SCHEMBL24196046 | 0.85 | ASH1L (0.65) | ASH1LPRKCIBRD4PIK3CDHPGDS | |
| SCHEMBL19586716 | 0.85 | ASH1L (1.00) | ASH1LPIK3CDPIK3CBCSNK2BCSNK2A1 | |
| SCHEMBL3675588 | 0.82 | ASH1L (0.74) | ASH1LPRKCIBRD4CSNK2A1ABL1 | |
| SCHEMBL8440311 | 0.81 | ASH1L (0.60) | ASH1LPRKCIPIK3CDHPGDSPIK3CB | |
| SCHEMBL10945814 | 0.78 | PIK3CD (0.75) | ASH1LPIK3CDHPGDSPIK3CBCDK8 | |
| SCHEMBL8440591 | 0.78 | ASH1L (0.56) | ASH1LPRKCIBRD4PIK3CDHPGDS | |
| SCHEMBL982028 | 0.78 | ASH1L (0.63) | ASH1LPIK3CDPIK3CBCSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642788-B2 | Activators of executioner procaspases 3, 6 and 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-02-04 | — | — | US | disclosed |
| CN-101965189-A | Activators of pro-caspase 3, 6 and 7 | UNIV CALIFORNIA | 2011-02-02 | — | — | CN | disclosed |
| EP-2237784-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | The Regents of the University of California (US) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009089508-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-07-16 | — | — | WO | disclosed |