Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD known ✓ | O00329 | 2/20 | 0.39 |
| ▸ | ABL1 known ✓ | P00519 | 1/20 | 0.38 |
| ▸ | PIK3CB known ✓ | P42338 | 1/20 | 0.38 |
| ▸ | ASH1L | Q9NR48 | 4/20 | 0.56 |
| ▸ | HPGDS | O60760 | 5/20 | 0.45 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.44 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.44 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | TAF1 | P21675 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8440983 | 0.79 | SLC9A1 (0.41) | — | |
| SCHEMBL8444494 | 0.79 | F10 (0.36) | PRKCI | |
| SCHEMBL3661287 | 0.78 | ASH1L (0.74) | ASH1LHPGDSPRKCIBTKBRD4 | |
| SCHEMBL27359861 | 0.78 | SERPINE1 (0.52) | PRKCI | |
| Hydrochloric Acid SCHEMBL8700277 | 0.77 | F10 (0.51) | — | |
| SCHEMBL27501518 | 0.77 | ASH1L (0.52) | ASH1LHPGDSPIP4K2APIP4K2BPIP4K2C | |
| SCHEMBL27378062 | 0.76 | BRD4 (0.38) | TAF1BRD4 | |
| Hydrochloric Acid SCHEMBL8700266 | 0.76 | SERPINE1 (0.53) | PRKCI | |
| SCHEMBL8703819 | 0.76 | KAT6A (0.53) | — | |
| SCHEMBL8441025 | 0.76 | GPR52 (0.40) | TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968985-A | INHIBITORS OF SODIUM ION/HYDROGEN ION EXCHANGE IN CELLS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| CN-1158606-A | Benzoylguanidine derivatives as medicaments | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-09-03 | — | — | CN | disclosed |
| EP-0773927-A2 | BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996004241-A2 | BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-15 | — | — | WO | disclosed |