Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.67 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.51 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.51 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.51 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.50 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | HPGDS | O60760 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | PRKCI | P41743 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24196046 | 0.86 | ASH1L (0.65) | ASH1LPIK3CDFTOPIK3CBHPGDS | |
| SCHEMBL3661287 | 0.86 | ASH1L (0.74) | ASH1LPIK3CDMAP2K4FTOPIK3CB | |
| SCHEMBL2947880 | 0.86 | PIK3CD (0.57) | ASH1LPIK3CDMAP2K4FTOAURKA | |
| SCHEMBL12171947 | 0.83 | ATR (0.49) | ASH1LPIK3CDMAPK1MAP2K4MAPKAPK3 | |
| SCHEMBL8440311 | 0.82 | ASH1L (0.60) | ASH1LPIK3CDPIK3CBHPGDSPRKCI | |
| SCHEMBL5830596 | 0.82 | HPGDS (0.60) | ASH1LPIK3CDFTOAURKATPX2 | |
| SCHEMBL6321711 | 0.80 | ASH1L (0.60) | ASH1LPIK3CDFTOPIK3CBHPGDS | |
| SCHEMBL21004055 | 0.80 | ASH1L (0.74) | ASH1LPIK3CDMAPK1FTOPIK3CB | |
| SCHEMBL30593676 | 0.80 | ASH1L (1.00) | ASH1LPIK3CDMAPK1PIK3CB | |
| SCHEMBL19586716 | 0.80 | ASH1L (1.00) | ASH1LPIK3CDMAPK1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220127266-A1 | MALIC ENZYME INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2022-04-28 | — | — | US | disclosed |
| US-11225480-B2 | Malic enzyme inhibitors | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2022-01-18 | — | — | US | disclosed |
| US-20210115038-A1 | MALIC ENZYME INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2021-04-22 | — | — | US | disclosed |
| WO-2021074898-A1 | MALIC ENZYME INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2021-04-22 | — | — | WO | disclosed |
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |
| US-20040157909-A1 | 4-Aryl substituted indolinones | SUGEN, INC. | 2004-08-12 | — | — | US | disclosed |
| US-6677368-B2 | 4-aryl substituted indolinones | SUGEN, INC. | 2004-01-13 | — | — | US | disclosed |
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| US-20030069297-A1 | 4-aryl substituted indolinones | SUGEN, INC. | 2003-04-10 | — | — | US | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069297-A1 | 4-aryl substituted indolinones | CDK5, CAMK4, TNK2 | ASH1L 1883/4885PIK3CD 365/4885MAPK1 296/4885 |
| US-20210115038-A1 | MALIC ENZYME INHIBITORS | ME1, ME2, ME3 | ASH1L 2683/4885PIK3CD 2594/4885MAPK1 1199/4885 |
| US-11225480-B2 | Malic enzyme inhibitors | ME1, RNASE1, ME2 | ASH1L 2739/4885PIK3CD 3514/4885MAPK1 378/4885 |
| US-20220127266-A1 | MALIC ENZYME INHIBITORS | ME1, ME2, ME3 | ASH1L 2683/4885PIK3CD 2594/4885MAPK1 1199/4885 |
| US-20040157909-A1 | 4-Aryl substituted indolinones | CDK5, CAMK4, TNK2 | ASH1L 1883/4885PIK3CD 365/4885MAPK1 296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.