Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.60 |
| ▸ | HTT | P42858 | 6/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1881522 | 0.92 | PIK3CD (0.67) | LMNAHTTMAPK1SMN1; SMN2PIK3CD | |
| SCHEMBL1887223 | 0.83 | PIK3CD (0.67) | LMNAHTTMAPK1SMN1; SMN2PIK3CD | |
| SCHEMBL3654897 | 0.82 | PIK3CD (0.68) | LMNAHTTPIK3CDPIK3CGTSHR | |
| SCHEMBL4436004 | 0.82 | HTT (0.54) | LMNAHTTMAPK1SMN1; SMN2PIK3CD | |
| SCHEMBL1879213 | 0.81 | PIK3CD (0.61) | LMNAHTTMAPK1SMN1; SMN2PIK3CD | |
| SCHEMBL4176220 | 0.80 | LMNA (0.53) | LMNAHTTMAPK1SMN1; SMN2PIK3CD | |
| SCHEMBL1888908 | 0.80 | PIK3CD (0.84) | PIK3CDPIK3CGMAPTMEN1KMT2A | |
| SCHEMBL1884069 | 0.80 | PIK3CG (0.75) | LMNASMN1; SMN2PIK3CDPIK3CGHSD17B10 | |
| SCHEMBL4434824 | 0.77 | LMNA (0.42) | LMNAHTTMAPK1SMN1; SMN2PIK3CD | |
| SCHEMBL1883935 | 0.76 | PIK3CD (0.60) | LMNAHTTMAPK1SMN1; SMN2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231641-A2 | QUINOXALINE AND QUINOLINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009081105-A2 | QUINOXALINE AND QUINOLINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2009-07-02 | — | — | WO | disclosed |