Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | PRKACA | P17612 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | LTK | P29376 | 1/20 | 0.53 |
| ▸ | GRK5 | P34947 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433351 | 0.88 | MAP4K4 (0.41) | HTTLMNASMN1; SMN2MAPK1AURKA | |
| SCHEMBL4176220 | 0.84 | LMNA (0.53) | HTTLMNASMN1; SMN2MAPK1AURKA | |
| SCHEMBL3661401 | 0.82 | LMNA (0.60) | HTTLMNASMN1; SMN2MAPK1TAAR1 | |
| SCHEMBL16799113 | 0.81 | LMNA (0.39) | HTTLMNASMN1; SMN2MAPK1AURKA | |
| SCHEMBL4434824 | 0.80 | LMNA (0.42) | HTTLMNASMN1; SMN2MAPK1AURKA | |
| SCHEMBL4435767 | 0.79 | MAP4K4 (0.40) | HTTLMNASMN1; SMN2MAPK1AURKA | |
| SCHEMBL27781229 | 0.79 | PIK3CD (0.66) | PIK3CDPIK3CG | |
| SCHEMBL4178088 | 0.79 | PIK3CD (0.66) | PIK3CDPIK3CG | |
| SCHEMBL4435698 | 0.78 | HTT (0.37) | HTTLMNASMN1; SMN2MAPK1AURKA | |
| SCHEMBL4434206 | 0.76 | HTT (0.38) | HTTLMNASMN1; SMN2MAPK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |