Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3662116 | 0.94 | PDGFRB (0.39) | LRRK2PDGFRBKDRCDK4CCND1 | |
| SCHEMBL3662766 | 0.87 | PKMYT1 (0.39) | PKMYT1CCNT1CDK9KDRCDK1 | |
| SCHEMBL3664695 | 0.85 | PLK1 (0.39) | CDK9KDRCCNA2CDK2 | |
| SCHEMBL1617684 | 0.83 | PSEN1 (0.53) | — | |
| SCHEMBL3657821 | 0.83 | PLK1 (0.39) | PDGFRBKDRCCNA2CDK2CDK5 | |
| SCHEMBL3664634 | 0.82 | PSEN1 (0.39) | CDK1CDK4CCNB1CCND1CCNE1 | |
| SCHEMBL3665907 | 0.81 | PLK1 (0.39) | KDRCCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL3663912 | 0.81 | PSEN1 (0.40) | CDK1CDK4CCNB1CCND1CCNE1 | |
| SCHEMBL3661161 | 0.80 | PLK1 (0.38) | KDRCDK1CCNB1CCNA2CDK2 | |
| SCHEMBL3666124 | 0.80 | PLK1 (0.39) | PDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231629-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009087127-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-16 | — | — | WO | disclosed |