Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 10/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.37 |
| ▸ | KDR | P35968 | 5/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1617479 | 0.81 | PSEN1 (0.53) | — | |
| SCHEMBL3664695 | 0.80 | PLK1 (0.39) | PLK1TNK2KDRINSRPTK2 | |
| SCHEMBL3661445 | 0.80 | LRRK2 (0.40) | KDRPDGFRB | |
| SCHEMBL3662116 | 0.79 | PDGFRB (0.39) | PLK1TNK2KDRPDGFRB | |
| SCHEMBL3657821 | 0.77 | PLK1 (0.39) | PLK1KDRPDGFRBINSRPTK2 | |
| SCHEMBL3665907 | 0.76 | PLK1 (0.39) | PLK1KDRPTK2 | |
| SCHEMBL3661174 | 0.74 | PLK1 (0.37) | PLK1KDRPDGFRBPTK2 | |
| SCHEMBL3661161 | 0.74 | PLK1 (0.38) | PLK1KDR | |
| SCHEMBL3408826 | 0.74 | CYP17A1 (0.42) | PLK1KDRINSRPTK2AURKB | |
| SCHEMBL3662766 | 0.74 | PKMYT1 (0.39) | PLK1TNK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231629-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009087127-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-16 | — | — | WO | disclosed |