Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 5/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3645386 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPK1FAAHATMPOLB | |
| SCHEMBL4683920 | 0.86 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPK1FAAHATMPOLB | |
| SCHEMBL844276 | 0.86 | CTSS (0.50) | SMN1; SMN2MAPK1FAAHATMGPR88 | |
| SCHEMBL844277 | 0.86 | CTSS (0.50) | SMN1; SMN2MAPK1FAAHATMGPR88 | |
| SCHEMBL4686341 | 0.86 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPK1FAAHATMPOLB | |
| SCHEMBL5505866 | 0.85 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPK1FAAHATMPOLB | |
| SCHEMBL4685965 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPK1FAAHATMPOLB | |
| SCHEMBL4685821 | 0.82 | ATM (0.63) | SMN1; SMN2MAPK1FAAHATMPOLB | |
| SCHEMBL7271316 | 0.81 | POLB (0.53) | SMN1; SMN2MAPK1FAAHPOLBLMNA | |
| SCHEMBL5222244 | 0.81 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPK1FAAHATMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234982-A1 | SUBSTITUTED HYDANTOINS AS MEK KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009080523-A1 | SUBSTITUTED HYDANTOINS AS MEK KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-02 | — | — | WO | disclosed |