Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | FAAH | O00519 | 3/20 | 0.47 |
| ▸ | ACACB | O00763 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4685965 | 0.91 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPK1FAAHACACBATM | |
| SCHEMBL4686341 | 0.90 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPK1FAAHACACBATM | |
| SCHEMBL3645386 | 0.89 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPK1FAAHACACBATM | |
| SCHEMBL5505866 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPK1FAAHACACBATM | |
| SCHEMBL3661621 | 0.86 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPK1FAAHACACBATM | |
| SCHEMBL3648170 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPK1FAAHACACBATM | |
| SCHEMBL4685821 | 0.84 | ATM (0.63) | SMN1; SMN2MAPK1FAAHATMPOLB | |
| SCHEMBL3376667 | 0.83 | CTSS (0.48) | SMN1; SMN2MAPK1FAAHACACBATM | |
| SCHEMBL5222244 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPK1FAAHACACBATM | |
| SCHEMBL3376664 | 0.83 | CTSS (0.48) | SMN1; SMN2MAPK1FAAHACACBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989186-A1 | HYDANTOIN BASED KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-12 | — | — | EP | disclosed |
| WO-2008101840-A1 | COMBINATION OF ERLOTINIB AND MEK-INHIBITORS FOR INHIBITING PROLIFERATION OF TUMOR CELLS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-28 | — | — | WO | disclosed |
| WO-2007096259-A1 | HYDANTOIN BASED KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-30 | — | — | WO | disclosed |