Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366244 | 0.91 | PSEN1 (0.41) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL365511 | 0.90 | KMT2A (0.39) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL364749 | 0.90 | ESR1 (0.38) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL367540 | 0.90 | PSEN1 (0.45) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL365979 | 0.89 | ALDH1A1 (0.36) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL366275 | 0.89 | ALDH1A1 (0.36) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL364902 | 0.89 | ALDH1A1 (0.40) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL365753 | 0.88 | ALDH1A1 (0.35) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL365359 | 0.88 | ALDH1A1 (0.47) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL364973 | 0.88 | KMT2A (0.42) | TSHRPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |