Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 10/20 | 0.36 |
| ▸ | PDE4A | P27815 | 9/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1750791 | 0.86 | PDE4D (0.36) | PDE4DPDE4APDE4BPDE4CPTGS2 | |
| SCHEMBL1750790 | 0.86 | PDE4D (0.36) | PDE4DPDE4APDE4BPDE4CPTGS2 | |
| SCHEMBL1750793 | 0.86 | PDE4D (0.36) | PDE4DPDE4APDE4BPDE4CPTGS2 | |
| SCHEMBL3655199 | 0.85 | PDE4D (0.39) | PDE4DPDE4APDE4BPDE4CPTGS2 | |
| SCHEMBL3662561 | 0.82 | PTGS2 (0.37) | PDE4DPDE4APDE4BPDE4CPTGS2 | |
| SCHEMBL1751689 | 0.82 | PTGS2 (0.38) | PDE4DPDE4APDE4BPDE4CPTGS2 | |
| SCHEMBL1750624 | 0.75 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL4033314 | 0.73 | PDE4D (0.59) | PDE4DPDE4APDE4BPDE4CPTGS2 | |
| SCHEMBL1751225 | 0.73 | PTGS2 (0.41) | PDE4DPDE4APDE4BPDE4CPTGS2 | |
| SCHEMBL1751223 | 0.73 | PTGS2 (0.41) | PDE4DPDE4APDE4BPDE4CPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225205-A1 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.p.A. (IT) | 2010-09-08 | — | — | EP | claimed |
| WO-2009077068-A9 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMA SPA (IT) | 2009-08-20 | — | — | WO | claimed |
| WO-2009077068-A1 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-06-25 | — | — | WO | claimed |