Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorene SCHEMBL7203740 | 1.00 | MAOA (0.48) | MAOAHTR2AKDM4EALDH1A1MAPT | |
| SCHEMBL29884836 | 0.85 | MAOA (0.52) | MAOAHTR2AKDM4EALDH1A1MAPT | |
| SCHEMBL29376368 | 0.85 | MAOA (0.52) | MAOAHTR2AKDM4EALDH1A1MAPT | |
| SCHEMBL216862 | 0.85 | MAOA (0.52) | MAOAHTR2AKDM4EALDH1A1MAPT | |
| Fluorene SCHEMBL28745577 | 0.83 | MAOA (0.65) | MAOAKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8272136 | 0.80 | HTR2A (0.61) | MAOAHTR2AHRH1HTR2CCYP1A2 | |
| Fluorene SCHEMBL29355380 | 0.80 | MAOA (0.68) | MAOAKDM4EALDH1A1MAPTSMN1; SMN2 | |
| Fluorene SCHEMBL31388525 | 0.80 | MAOA (0.68) | MAOAKDM4EALDH1A1MAPTSMN1; SMN2 | |
| Fluorene SCHEMBL29478468 | 0.80 | MAOA (0.68) | MAOAKDM4EALDH1A1MAPTSMN1; SMN2 | |
| Fluorene SCHEMBL8180 | 0.80 | MAOA (0.68) | MAOAKDM4EALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2207877-A2 | MUTANT ENZYMES | ISIS Innovation Limited (GB) | 2010-07-21 | — | — | EP | disclosed |
| WO-2009047498-A2 | MUTANT ENZYMES | ISIS INNOVATION LIMITED (GB) | 2009-04-16 | — | — | WO | disclosed |