Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.54 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.49 |
| ▸ | TDP2 | O95551 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 2/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | BCL6 | P41182 | 1/20 | 0.48 |
| ▸ | BCOR | Q6W2J9 | 1/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.46 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422966 | 0.81 | BCL6 (0.60) | GRIA1CACNG8DYRK1APDE3BPDE3A | |
| SCHEMBL29511878 | 0.81 | BCL6 (0.60) | GRIA1CACNG8DYRK1APDE3BPDE3A | |
| SCHEMBL2431097 | 0.79 | PARP1 (0.64) | TDP2ERN1CCNT1CCND1CCNC | |
| SCHEMBL31422694 | 0.79 | PARP1 (0.64) | TDP2ERN1CCNT1CCND1CCNC | |
| SCHEMBL22191078 | 0.78 | VNN1 (0.54) | DYRK1AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6999225 | 0.77 | DHODH (0.63) | TDP2ERN1CCNT1CCND1CCNC | |
| SCHEMBL980513 | 0.77 | GRIA1 (0.60) | GRIA1CACNG8TDP2PDE3BPDE3A | |
| SCHEMBL18632516 | 0.76 | PDE3B (0.67) | GRIA1CACNG8DYRK1APDE3BPDE3A | |
| SCHEMBL2589651 | 0.76 | ERN1 (0.60) | TDP2ERN1PARP1DHODH | |
| SCHEMBL29941476 | 0.76 | DHODH (0.68) | TDP2ERN1PARP1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642788-B2 | Activators of executioner procaspases 3, 6 and 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-02-04 | — | — | US | disclosed |
| CN-101965189-A | Activators of pro-caspase 3, 6 and 7 | UNIV CALIFORNIA | 2011-02-02 | — | — | CN | disclosed |
| EP-2237784-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | The Regents of the University of California (US) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009089508-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-07-16 | — | — | WO | disclosed |