Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 4/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2990063 | 0.86 | ALOX5AP (0.52) | ALOX5APTLR9TLR8TLR7JAK2 | |
| SCHEMBL3001060 | 0.82 | ALOX5AP (0.64) | ALOX5APTLR9TLR8TLR7JAK2 | |
| SCHEMBL17184739 | 0.76 | KEAP1 (0.40) | TLR9TLR8TLR7CHRNA7 | |
| SCHEMBL480232 | 0.76 | ALOX5AP (0.65) | ALOX5APTLR9TLR8TLR7JAK2 | |
| SCHEMBL480207 | 0.76 | ALOX5AP (0.65) | ALOX5APTLR9TLR8TLR7JAK2 | |
| SCHEMBL933581 | 0.76 | NOS3 (0.40) | TLR9TLR8TLR7CHRNA7 | |
| SCHEMBL2609362 | 0.75 | MAOB (0.43) | — | |
| SCHEMBL13262239 | 0.74 | ALOX5AP (0.60) | ALOX5APTLR9TLR8TLR7 | |
| SCHEMBL480220 | 0.74 | ALOX5AP (0.80) | ALOX5APJAK2 | |
| SCHEMBL480102 | 0.74 | ALOX5AP (0.80) | ALOX5APJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170065-A1 | DIPHENYL SUBSTITUTED ALKANES | Merck Sharp & Dohme Corp. (US) | 2010-04-07 | — | — | EP | claimed |
| WO-2008156721-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | claimed |