Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 4/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856419 | 0.88 | ALDH1A1 (0.45) | DPP8DPP9DPP7DPP4EPHX2 | |
| SCHEMBL19732237 | 0.88 | ALDH1A1 (0.45) | DPP8DPP9DPP7DPP4EPHX2 | |
| SCHEMBL15309876 | 0.88 | ALDH1A1 (0.45) | DPP8DPP9DPP7DPP4EPHX2 | |
| SCHEMBL1250452 | 0.88 | ALDH1A1 (0.45) | DPP8DPP9DPP7DPP4EPHX2 | |
| SCHEMBL1666704 | 0.88 | ALDH1A1 (0.45) | DPP8DPP9DPP7DPP4EPHX2 | |
| SCHEMBL1250453 | 0.88 | ALDH1A1 (0.45) | DPP8DPP9DPP7DPP4EPHX2 | |
| SCHEMBL19856434 | 0.88 | ALDH1A1 (0.45) | DPP8DPP9DPP7DPP4EPHX2 | |
| SCHEMBL1250455 | 0.88 | ALDH1A1 (0.45) | DPP8DPP9DPP7DPP4EPHX2 | |
| Hydrochloric Acid SCHEMBL16611847 | 0.86 | ALDH1A1 (0.44) | DPP8DPP9DPP7DPP4EPHX2 | |
| Oxalic Acid SCHEMBL19856452 | 0.85 | ALDH1A1 (0.43) | DPP8DPP9DPP7DPP4EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2666774-B1 | Beta-lactamase Inhibitors | MERCK SHARP & DOHME (US) | 2015-01-07 | — | — | EP | disclosed |
| EP-2666774-A1 | Beta-lactamase Inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-11-27 | — | — | EP | disclosed |
| US-20130274475-A1 | BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME (US) | 2013-10-17 | — | — | US | disclosed |
| EP-2231667-B1 | BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME (US) | 2013-09-04 | — | — | EP | disclosed |
| US-8487093-B2 | β-lactamase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20110294777-A1 | BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2011-12-01 | — | — | US | disclosed |
| EP-2231667-A2 | BETA-LACTAMASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009091856-A2 | BETA-LACTAMASE INHIBITORS | MERCK & CO., INC. (US) | 2009-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294777-A1 | BETA-LACTAMASE INHIBITORS | MGAM, RPIA, LBR | DPP8 1086/4885DPP9 368/4885DPP7 821/4885 |
| US-20130274475-A1 | BETA-LACTAMASE INHIBITORS | MGAM, RPIA, XDH | DPP8 966/4885DPP9 284/4885DPP7 745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.