Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL441105 | 0.75 | LMNA (0.42) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9093746 | 0.71 | LMNA (0.71) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5133066 | 0.70 | LMNA (0.72) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2185035 | 0.70 | MAPT (0.46) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19439 | 0.69 | NOTUM (0.39) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL7014996 | 0.69 | MAPT (0.51) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2412002 | 0.69 | NOTUM (0.39) | KDM4ENPC1RAB9AL3MBTL1GAA | |
| SCHEMBL1515426 | 0.69 | NISCH (0.38) | KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4590846 | 0.69 | MAPK14 (0.35) | MAPTNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL5797199 | 0.68 | MAPT (0.43) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231602-A1 | GAMMA SECRETASE MODULATORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009075874-A1 | GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-06-18 | — | — | WO | disclosed |