Sugi Predict

Sugi Predict / Compounds / SCHEMBL4590846

SCHEMBL4590846

SCHEMBL4590846

Fc1ccc(-c2[c]nccc2)cc1

nearest known ligand 0.35

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MAPK14 Q16539 8/20 0.35
▸ MAPK10 P53779 1/20 0.35
▸ NPC1 O15118 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ CYP19A1 P11511 1/20 0.33
▸ TDO2 P48775 1/20 0.32
▸ GCGR P47871 2/20 0.32
▸ TOP1 P11387 1/20 0.32
▸ ALOX5 P09917 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ MAPT P10636 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ GFER P55789 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ MAPK13 O15264 1/20 0.31
▸ MAPK12 P53778 1/20 0.31
▸ MAPK11 Q15759 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6188099 0.82 NOTUM (0.37) —
SCHEMBL19439 0.80 NOTUM (0.39) NPC1RAB9ACYP19A1ALDH1A1KMT2A
SCHEMBL2412002 0.79 NOTUM (0.39) NPC1RAB9ACYP19A1TDO2GCGR
SCHEMBL5318660 0.79 NISCH (0.41) MAPTKMT2A
SCHEMBL5797199 0.78 MAPT (0.43) NPC1RAB9AALDH1A1MAPT
SCHEMBL4909130 0.77 — —
SCHEMBL5066564 0.75 CLK4 (0.48) NPC1RAB9ACYP19A1ALDH1A1MAPT
SCHEMBL5887656 0.75 MAPT (0.47) NPC1RAB9AALDH1A1MAPTHPGD
SCHEMBL5543084 0.74 KMO (0.38) —
SCHEMBL5121103 0.74 NISCH (0.43) ALDH1A1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3686187-A1 PROCESS FOR THE PREPARATION OF ROR GAMMA MODULATORS Glenmark Pharmaceuticals S.A. (CH) 2020-07-29 — — EP disclosed
US-10435374-B2 Heterocyclic compounds as pesticides BAYER CROPSCIENCE AG (DE) 2019-10-08 — — US disclosed
US-20190023709-A1 SHIP1 MODULATORS AND METHODS RELATED THERETO AQUINOX PHARMACEUTICALS CANADA INC (CA) 2019-01-24 — — US disclosed
US-10100056-B2 SHIP1 modulators and methods related thereto AQUINOX PHARMACEUTICALS (CANADA) INC. (CA) 2018-10-16 — — US disclosed
US-20170305864-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2017-10-26 — — US disclosed
US-20170253596-A2 SHIP1 MODULATORS AND METHODS RELATED THERETO TARO PHARMACEUTICALS INC. (CA) 2017-09-07 — — US disclosed
US-20160083387-A1 SHIP1 MODULATORS AND METHODS RELATED THERETO AQUINOX PHARMACEUTICALS CANADA INC (CA) 2016-03-24 — — US disclosed
EP-2970100-A1 SHIP1 MODULATORS AND METHODS RELATED THERETO Aquinox Pharmaceuticals (Canada) Inc. (CA) 2016-01-20 — — EP disclosed
CN-102532162-B 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles OTSUKA PHARMA CO LTD 2015-05-27 — — CN disclosed
WO-2014143561-A1 SHIP1 MODULATORS AND METHODS RELATED THERETO AQUINOX PHARMACEUTICALS INC. (CA) 2014-09-18 — — WO disclosed
CN-1889940-A Treatment of personality changes due to hot flashes, impulse control disorders and systemic medical conditions LILLY CO ELI (US) 2007-01-03 — — CN disclosed
EP-1706380-A1 DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF AstraZeneca AB (SE) 2006-10-04 — — EP disclosed
US-20060094767-A1 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-05-04 — — US disclosed
CN-1705670-A 2, 3-dihydro-6-nitroimidazo [2, 1-b ] oxazole compounds OTSUKA PHARMA CO LTD (JP) 2005-12-07 — — CN disclosed
WO-2005066128-A1 DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF ASTRAZENECA AB (SE) 2005-07-21 — — WO disclosed
EP-1555267-A1 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2005-07-20 — — EP disclosed
EP-1265870-A1 NEW CCR5 MODULATORS: BENZIMIDAZOLES OR BENZOTRIAZOLES AstraZeneca AB (SE) 2002-12-18 — — EP disclosed
WO-2001066525-A1 NEW CCR5 MODULATORS: BENZIMIDAZOLES OR BENZOTRIAZOLES ASTRAZENECA AB (SE) 2001-09-13 — — WO disclosed
US-5134150-A Administering diaryl-substituted imidazothiazoles; antiarthritic agents SMITHKLINE BEECHAM CORPORATION (US) 1992-07-28 — — US disclosed
CN-86108538-A The inhibition of 5-lipoxygenase pathway — 1987-07-29 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10435374-B2 Heterocyclic compounds as pesticides DDT, ACHE, PTMS MAPK14 3721/4885MAPK10 3927/4885NPC1 3509/4885
US-20170305864-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES DDT, ACHE, PTMS MAPK14 3721/4885MAPK10 3927/4885NPC1 3509/4885
US-20190023709-A1 SHIP1 MODULATORS AND METHODS RELATED THERETO PPM1D, PPP1R1B, PPM1A MAPK14 3173/4885MAPK10 1284/4885NPC1 1207/4885
US-20060094767-A1 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles NR2C2, NR4A3, NR4A2 MAPK14 2803/4885MAPK10 3706/4885NPC1 2404/4885
US-20160083387-A1 SHIP1 MODULATORS AND METHODS RELATED THERETO PPM1D, PPP1R1B, PPM1A MAPK14 3173/4885MAPK10 1284/4885NPC1 1207/4885
US-20170253596-A2 SHIP1 MODULATORS AND METHODS RELATED THERETO PPM1D, PPP1R1B, PPM1A MAPK14 3173/4885MAPK10 1284/4885NPC1 1207/4885
US-10100056-B2 SHIP1 modulators and methods related thereto PPM1D, PPP1R1B, PPM1A MAPK14 3173/4885MAPK10 1284/4885NPC1 1207/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.