Indole

Indole

SCHEMBL3662699

O=C(O)Cc1cc2ccccc2[nH]1.c1ccc2[nH]ccc2c1

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
ITGB2 P05107 1/20 0.50
ICAM1 P05362 1/20 0.50
ITGAL P20701 1/20 0.50
CA4 P22748 1/20 0.50
CA6 P23280 1/20 0.50
AHR P35869 1/20 0.50
ADK P55263 1/20 0.50
AKR1B1 P15121 1/20 0.47
NLRP3 Q96P20 1/20 0.47
CTNNB1 P35222 1/20 0.47
WNT3A P56704 1/20 0.47
LOXL2 Q9Y4K0 1/20 0.46
MTNR1A P48039 1/20 0.46
MTNR1B P49286 1/20 0.46
IDO1 P14902 1/20 0.46
MAPT P10636 2/20 0.45
KDM4E B2RXH2 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indole SCHEMBL29627418 0.96 MTNR1A (0.49) TRPA1CA1CA2ITGB2ICAM1
SCHEMBL31336079 0.89 LOXL2 (0.56) AKR1B1NLRP3LOXL2MTNR1AMTNR1B
SCHEMBL49270 0.89 LOXL2 (0.56) AKR1B1NLRP3LOXL2MTNR1AMTNR1B
SCHEMBL29365671 0.89 LOXL2 (0.56) AKR1B1NLRP3LOXL2MTNR1AMTNR1B
Water SCHEMBL30025993 0.88 LOXL2 (0.55) AKR1B1NLRP3LOXL2MTNR1AMTNR1B
SCHEMBL31511816 0.88 LOXL2 (0.55) AKR1B1NLRP3LOXL2MTNR1AMTNR1B
Indole SCHEMBL28354967 0.83 MTNR1A (0.48) TRPA1CA1CA2ITGB2ICAM1
SCHEMBL29396052 0.82 AKR1B1 (0.49) AKR1B1NLRP3LOXL2MTNR1AMTNR1B
SCHEMBL1576841 0.80 POLB (0.46) AKR1B1NLRP3LOXL2MTNR1AMTNR1B
Phenylacetic Acid SCHEMBL26643888 0.80 AKR1B1 (0.59) TRPA1CA1CA2ITGB2ICAM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2217259-A2 METHODS FOR TREATMENT OF THIOL-CONTAINING COMPOUND DEFICIENT CONDITIONS National Jewish Health (US) 2010-08-18 EP disclosed
WO-2009052411-A2 METHODS FOR TREATMENT OF THIOL-CONTAINING COMPOUND DEFICIENT CONDITIONS NATIONAL JEWISH MEDICAL AND RESEARCH CENTER (US) 2009-04-23 WO disclosed
EP-1954681-A2 COMPOUNDS AND METHODS FOR THIOL-CONTAINING COMPOUND EFFLUX AND CANCER TREATMENT National Jewish Medical and Research Center (US) 2008-08-13 EP disclosed
EP-1931345-A2 METHODS FOR TREATMENT OF THIOL-CONTAINING COMPOUND DEFICIENT CONDITIONS National Jewish Medical and Research Center (US) 2008-06-18 EP disclosed
WO-2007073518-A9 COMPOUNDS AND METHODS FOR THIOL-CONTAINING COMPOUND EFFLUX AND CANCER TREATMENT NAT JEWISH MED & RES CENTER (US) 2007-08-23 WO disclosed
WO-2007073518-A2 COMPOUNDS AND METHODS FOR THIOL-CONTAINING COMPOUND EFFLUX AND CANCER TREATMENT NATIONAL JEWISH MEDICAL AND RESEARCH CENTER (US) 2007-06-28 WO disclosed
WO-2007024741-A2 METHODS FOR TREATMENT OF THIOL-CONTAINING COMPOUND DEFICIENT CONDITIONS NATIONAL JEWISH MEDICAL AND RESEARCH CENTER (US) 2007-03-01 WO disclosed