Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366285 | 0.83 | ALDH1A1 (0.54) | MAPTGAARXFP1LMNATSHR | |
| SCHEMBL365016 | 0.81 | KDM4E (0.50) | MAPTTSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL365361 | 0.80 | PPARG (0.49) | GAASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL364761 | 0.78 | KDM4E (0.52) | MAPTGAALMNATSHRMAPK1 | |
| SCHEMBL364969 | 0.76 | KDM4E (0.53) | MAPTGAALMNATSHRMAPK1 | |
| SCHEMBL364770 | 0.76 | ELANE (0.48) | MAPTGAALMNAMAPK1MEN1 | |
| SCHEMBL364713 | 0.75 | NPSR1 (0.48) | MAPTLMNATSHRNPSR1MAPK1 | |
| SCHEMBL366638 | 0.74 | KDM4E (0.47) | MAPTGAALMNANPSR1MAPK1 | |
| SCHEMBL367142 | 0.74 | KDM4E (0.47) | MAPTGAALMNAMAPK1SMN1; SMN2 | |
| SCHEMBL364758 | 0.73 | MEN1 (0.44) | MAPTGAALMNATSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |