Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 16/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4639209 | 0.86 | MTNR1B (0.41) | MTNR1BMTNR1A | |
| SCHEMBL3664188 | 0.83 | MTNR1B (0.39) | MTNR1BAKR1C3 | |
| SCHEMBL3657289 | 0.80 | MTNR1B (0.37) | MTNR1BMTNR1A | |
| SCHEMBL4032581 | 0.79 | MTNR1B (0.48) | MTNR1BMTNR1A | |
| SCHEMBL2123940 | 0.78 | MTNR1B (0.47) | MTNR1BMTNR1A | |
| SCHEMBL3664253 | 0.78 | MTNR1B (0.47) | MTNR1BMTNR1A | |
| SCHEMBL4638202 | 0.77 | MTNR1B (0.35) | MTNR1BMTNR1A | |
| SCHEMBL2984099 | 0.77 | DPP4 (0.38) | AKR1C3SRD5A1 | |
| SCHEMBL2123210 | 0.75 | MTNR1B (0.45) | MTNR1BMTNR1AAKR1C3 | |
| SCHEMBL2123219 | 0.73 | MTNR1B (0.43) | MTNR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222669-A1 | OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (SIP) | Glaxo Group Limited (GB) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009080725-A1 | OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (SIP) | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |