Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364234 | 0.94 | ALDH1A1 (0.45) | EGFRSRCALDH1A1HPGDPTGER4 | |
| SCHEMBL366390 | 0.94 | ALDH1A1 (0.45) | EGFRSRCALDH1A1HPGDPTGER4 | |
| SCHEMBL361357 | 0.91 | EGFR (0.51) | EGFRSRCALDH1A1HPGDPTGER4 | |
| SCHEMBL365858 | 0.90 | ALDH1A1 (0.47) | ALDH1A1TDP1POLBMAPTRAD52 | |
| SCHEMBL366312 | 0.88 | ALDH1A1 (0.52) | ALDH1A1TDP1POLBMAPTKDM4E | |
| SCHEMBL364813 | 0.88 | ALDH1A1 (0.46) | EGFRSRCALDH1A1TDP1POLB | |
| SCHEMBL365411 | 0.86 | ALDH1A1 (0.53) | ALDH1A1TDP1POLBMAPTKDM4E | |
| SCHEMBL366536 | 0.86 | EGFR (0.53) | EGFRSRCALDH1A1HPGDPTGER4 | |
| SCHEMBL366302 | 0.85 | ALDH1A1 (0.47) | ALDH1A1TDP1POLBMAPTKDM4E | |
| SCHEMBL366412 | 0.85 | ALDH1A1 (0.49) | EGFRSRCALDH1A1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |