Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | SELL | P14151 | 1/20 | 0.33 |
| ▸ | SELP | P16109 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3659739 | 0.86 | OPRM1 (0.36) | THRATHRB | |
| SCHEMBL3661404 | 0.84 | OPRM1 (0.36) | THRATHRB | |
| SCHEMBL15112552 | 0.81 | MEN1 (0.36) | THRBCNR2MEN1KMT2ATSHR | |
| SCHEMBL3663585 | 0.81 | MEN1 (0.43) | CNR2MEN1KMT2ATSHRAKR1C1 | |
| SCHEMBL15112675 | 0.79 | ALDH1A1 (0.36) | THRBCNR2MEN1KMT2ATSHR | |
| SCHEMBL15111291 | 0.77 | APP (0.46) | AKR1C1MAP4K4 | |
| SCHEMBL15112699 | 0.73 | MEN1 (0.40) | CNR2MEN1KMT2ATSHRAKR1C1 | |
| SCHEMBL13968086 | 0.71 | OPRM1 (0.40) | MEN1KMT2AMAP4K4PDE4APDE4B | |
| SCHEMBL13968084 | 0.70 | MAP4K4 (0.39) | CNR2MEN1KMT2ATSHRMAP4K4 | |
| SCHEMBL3654280 | 0.70 | PARP15 (0.37) | THRATHRBCNR2MAP4K4PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013106328-A1 | TETRASUBSTITUTED BENZENES FOR TREATMENT OF EARLY ONSET ALZHEIMER'S DISEASE | ENVIVO PHARMACEUTICALS, INC. (US) | 2013-07-18 | — | — | WO | disclosed |
| EP-2234954-A1 | TETRASUBSTITUTED BENZENES | Envivo Pharmaceuticals, Inc. (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009086277-A1 | TETRASUBSTITUTED BENZENES | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |